Adult stem cells to treat multiple sclerosis

Neural stem cells NSCs — glial cells Haffernan et al, 90 Clinical human model The study involved the designing of CPP sequence that selectively transduced human glial cells excluding nonglial cell types , and conducted preliminary screens of purified, recombinant CPPs with immature and matured human oligodendrocytes and astrocytes and two nonglial cell types to treat MS. Embryonic stem cells derived NSCs Payne et al, 91 Preclinical mouse model The study evaluated the therapeutic potential of NSCs derived from ES cells by two different neural differentiation protocols that utilized adherent culture conditions and compared their effect with primary NSCs derived from the subventricular zone SVZ. Hematopoietic stem cells HSCs Fassas and Kazis, 41 Clinical Phase I and II studies in human The study was based on concept of immune ablation by high-dose therapy and reconstitution of normal immunity from transplant-derived lymphocyte progenitors. Neural precursor stem cells NPSCs Donega et al, 93 Preclinical mouse model The study involved injecting NPSCs in mice model of experimental autoimmune encephalomyelitis EAE , via iv and icv route of administration, with chronic CNS inflammatory demyelination, and envisage the systemic stem cell delivery as a valuable technique for the selective targeting of the inflamed brain in regenerative neurology. Peripheral blood stem cells were derived by leukapheresis after mobilized with granulocyte colony-stimulating factor. Long-term responses were evaluated by the expanded disability status scale EDSS , progression-free survival, and gadolinium-enhanced magnetic resonance imaging scans.
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A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells

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Stem Cell Transplantation for the Treatment of MS -

Acknowledgements and references Multiple sclerosis MS is a disease that affects nerve cells in the brain and spinal cord. In the healthy body, these nerve cells carry messages between the brain and the rest of the body, allowing us to move, balance, see, hear and feel. Each nerve cell is wrapped in a protective sheath called myelin. If the myelin is damaged, the cell can no longer carry messages properly.
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Stem Cell Transplantation for the Treatment of MS

Heart The use of stem cells for the treatment of MS is an up-and-coming area of interest. Preliminary research is promising, however, much more study is needed to determine the safety, efficacy, and best practices involved with stem cell therapy for relapsing-remitting and progressive MS. What are stem cells?
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